The deterioration of neuroplasticity with age may be related to the deficiency of the serine racemase enzyme. This has been shown by a study published in the journal. Aging.
Aging is associated with deterioration in the performance of NMDA receptors. They play a central role in learning, memory formation, and neuroplasticity (the brain’s ability to change structure in response to new experiences). The amino acid D-serine is required for activation of NMDA receptors. The serine racemase enzyme is responsible for its formation.
In a new study, scientists evaluated serine racemase content in the brains of old and young mice. It turned out that the production of this enzyme in the hippocampus decreases with age. The hippocampus is the area of ​​the brain responsible for converting short-term memories into long-term memories.
The study authors suggest that a decrease in serine racemase production may impair the functioning of NMDA receptors and neuroplasticity of the brain. This discovery could form the basis of new methods to combat age-related memory loss.
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Source: Gazeta
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