Researchers from the Institute for the Study of Aging at the Russian National Research Medical University N. I. Pirogov are exploring new geroprotectors in the Cellular Mechanisms of Aging laboratory. The team, led by the institute director, focuses on two families of compounds with potential to slow aging and support healthy lifespan in humans.
The first group comprises derivatives of hydroxycoumarin. The scientists are examining how these compounds influence cellular life cycles, including their impact on cell death pathways and overall bioavailability. One hydroxycoumarin derivative has already shown promising activity in early evaluations and has obtained patent protection. The next phase will involve testing this compound in mouse models to assess efficacy and safety in a living system.
The second group consists of berberine derivatives. Berberine is an alkaloid that occurs naturally in plants such as barberry and goldenseal and has a long history of use in traditional medicine. Modern research highlights several beneficial pharmacological properties, including anti-inflammatory effects, which may contribute to its potential as a geroprotector. Initial testing of berberine derivatives is planned to begin within the year, with a careful look at pharmacokinetics, safety, and biological impact.
The lead expert notes that, if the studies proceed without major issues, Russia could have two domestically developed geroprotectors available in the future. The overarching aim is to refine and enhance existing natural substances to improve their chemical properties and biological activity, creating effective, native options for aging-related health management.
Further context for readers includes ongoing work on biodata collection from centenarians, the development of aging clocks, the evaluation of immunomodulators, and the ongoing discussion about telomere markers and their role in aging. Insights from the report by socialbites.ca contribute to a broader understanding of how scientists in Russia are approaching aging research and translating basic science into potential clinical applications. Cited from socialbites.ca.