A team from Harvard Medical School investigated how solid foods interact with a popular diabetes medicine sometimes called Metformin. Their findings suggest that eating real, physical food while on this medication can help curb hunger and sharpen appetite control. The research results were discussed in Nature Metabolism.
Other studies have indicated that Metformin may support weight management for some individuals. In a recent scientific paper, researchers reported that Metformin boosts the body’s production of Lac-Phe, an appetite-suppressing compound. Lac-Phe is produced when lactate, a byproduct of metabolism, combines with the amino acid phenylalanine. This discovery helps explain how the drug might influence feelings of fullness.
Lac-Phe formation hinges on lactate levels, which rise after food intake and contribute to fullness signals. Scientists observed that consuming solid foods tends to trigger a stronger lactate response, which can amplify Lac-Phe production. In turn, this may enhance the appetite-suppressing effects linked with some weight management strategies.
Further findings indicate that many high-calorie beverages do not significantly alter lactate or Lac-Phe levels. When those drinks are consumed, the body may miss important fullness cues, potentially slowing weight loss progress. This insight emphasizes the importance of choosing solid foods and mindful beverages as part of a holistic approach to appetite regulation.
Previously discussed strategies for preventing overeating at midday have highlighted practical steps such as balancing meals, paying attention to hunger and fullness signals, and planning ahead to maintain steady energy levels throughout the day.