Researchers Identify Lac-Phe and Its Link to Satiety After Exercise and Medication
Researchers at Stanford Medicine have observed that intense physical activity triggers the body to produce special molecules that influence metabolism. A substance similar to these satiety-promoting molecules can also be formed when a well-known diabetes drug is used. Findings were reported in Nature Metabolism, highlighting a connection between exercise, medication, and appetite regulation. (Nature Metabolism, 2023)
In studies analyzing blood samples from individuals with diabetes who used metformin, scientists found that a molecule named Lac-Phe emerges as a response to this therapy. Lac-Phe has earned the nickname the satiety molecule because of its potential to help normalize metabolism and support appetite control. The research suggests Lac-Phe might be a mediator linking blood sugar management to feelings of fullness after meals. (Nature Metabolism, 2023)
Further work indicates that Lac-Phe levels can rise not only through medication but also via physical exercise. When people engage in high intensity training, the production of these satiety-related molecules appears to accelerate, which may contribute to better appetite regulation in the post-workout period. (Nature Metabolism, 2023)
The metabolic story behind Lac-Phe involves the breakdown of glucose during strenuous activity, a process that helps lower blood glucose levels. At the same time, exercise increases the production of lactate in working muscles. Lactate is a byproduct of cellular metabolism that accumulates when muscles are pushed toward fatigue. Lac-Phe is understood as a composite of lactate and the amino acid phenylalanine, created through enzymatic pathways activated by muscular effort. (Nature Metabolism, 2023)
Experts explain that Lac-Phe formation after intense exercise may contribute to reduced hunger signals in the hours following a workout. This connection between physical activity and appetite suppression is being explored as part of broader research into metabolic health and weight management strategies. (Nature Metabolism, 2023)
Earlier discussions about nutrition and metabolism have raised questions about which foods support or hinder weight goals. The evolving science around Lac-Phe and similar metabolic signals adds a new layer to understanding how exercise and medication can influence hunger, energy balance, and metabolic efficiency. (Nature Metabolism, 2023)