Scientists from Tokyo Capital University have found that the malfunctions in glucose metabolism in gial cells – supporting the elements of the nervous system – alzheimer’s disease played an important role in the development of neurodegeneration. Research Results published Disease models and mechanisms (DMM).
Alzheimer’s disease is a leading cause of dementia in the elderly. Its development is associated with Tau-Belk, which constitutes insoluble deposits in the brain. However, it is still not clear how the pathological accumulation of Tau Belka causes the destruction of neurons.
Japanese researchers focused on glyial cells that supported the work of neurons and participated in the fight against inflammation. It is particularly important for the brain to provide energy, to process glucose. Fruit flies were used as a model. Scientists have found that insects have developed neurodegeneration associated with the violation of the function of the function of glyial cells.
When the researchers concentrated glucose intake to these cells, the process of inflammation and destruction of the tissues slowed down, although the TAU Belka level remained the same. This indicates that it is not only the presence of a pathological protein that can initiate degenerative processes, but they have energy failures.
Authors believe that the restoration of normal glucose metabolism in gial cells can become a new direction in the treatment of other neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease.
Previously, scientists ApprovedAfter 45 years, it reduces the risk of active life dementia.
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Source: Gazeta
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