Scientists from the University of Carnegie Mellon first printed a functional pancreatic tissue model on a 3D-bioprinter of collagen. To do this, they used a new technology called Fresh, allowing you to recreate soft biological structures correctly. Research Results published In Science Advances (SCIADV) magazine.
The generated model can produce insulin in response to glucose, which opens expectations for new treatment methods of the first type diabetes. In this type of diabetes, the pancreas stops producing it because of the destruction of β cells, so an absolute deficiency of this hormone occurs in the body. Scientists argue that such organoid implantation can reduce the need for daily insulin injections.
The fabric contains microchanals similar to blood vessels, about 100 microns (0.1 millimeters). Collagen, the most common protein in the human body, has become the basis of this innovative structure. Its use has traditionally made it possible to overcome the restrictions on the use of synthetic materials used in the organs on the “chip” devices. These materials could not completely reproduce the natural biological environment, which reduced the effectiveness of models in research and therapy.
Professor Adam Finberg, the head of the study, said, “Now we can create micro -ratified systems from other proteins with collagen, cells and unprecedented structural resolution and accuracy in the Petri Cup.”
The new 3D printing method is called the free-shaped burial of suspended hydrogels. It involves the formation of soft materials in a container with the base of the gelatin that protects the shape of an object, not in the air.
Previously, scientists Created Useful bacteria for diabetics.
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Source: Gazeta
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