Scientists from the University of New Mexico have developed an innovative “vaccine” to reduce the level of “bad” cholesterol in the blood. Research results published At NPJ Vaccines.
The new drug targets the protein PCSK9, a molecule produced in the liver. It negatively regulates the metabolism of LDL cholesterol by circulating in the bloodstream. LDL, or low-density lipoprotein, is a complex of proteins and lipids that transports cholesterol from the liver to cells. LDL is called “bad cholesterol” because such molecules are large, “stick” to microdamages inside blood vessels, sticking to the walls and forming atherosclerotic plaques.
Scientists explained that the level of PCSK9 in the body is directly related to the level of LDL cholesterol. The new “vaccine” is based on the use of non-infectious viral particles. The molecules of the substance are the protein shell of the virus. This fertile container of tiny PCSK9 particles enters the human body like a virus, causing the immune system to mount a strong immune response.
The effectiveness of the vaccine has already been proven in experiments on mice and monkeys. Scientists now plan to move on to tests on humans. The researchers also announced their intention to make a ready-to-use version of the vaccine available to the public. One dose of the substance (effectiveness lasts a year) is expected to cost less than $ 100 (about 9,196 rubles).
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Source: Gazeta
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