Scientists from Stanford University of Medicine have found a way to predict which human organ will malfunction first. The journal describes a method to assess the rate of organ aging using a blood test. Nature.
Scientists analyzed the levels of nearly 5,000 proteins in the blood of nearly 1,400 people aged 20 to 90. They then used a machine learning algorithm to identify 858 proteins that reliably predicted the biological age of the heart, adipose tissue, lung, immune system, kidney, liver, muscle, pancreas, brain, vascular system and intestine.
Another study involved 5,678 people. Analysis of their data confirmed that human organs age at different rates. If an organ aged particularly quickly, it was likely to cause serious illness or death.
About one in five relatively healthy adults aged 50 and over has at least one such organ, and one in 60 has two rapidly aging organs, scientists have found. For the former, the risk of death in the next 15 years is 15-50% higher, and for the latter it is 6.5 times higher (compared to a person without a clearly aged organ).
The study also found that people with accelerated heart aging who had no signs of active disease had a 2.5 times higher risk of heart failure than people with normal aging hearts. A rapidly aging brain increased the risk of memory loss by 1.8 times within five years.
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Source: Gazeta
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