Scientists have created genetically modified yeast that can synthesize the antidepressant glycoside orsine. article about it published On PLOS One.
“The transgenic yeast variety we have developed is capable of producing large amounts of orcine glycosides, the concentration of this substance in them exceeding the concentration in plant roots by about 6400 times. Thus, one cubic meter of these fungi will produce as much orcin as 1,500 square kilometers of medicinal plant.
To achieve this, biologists transplanted four plant genes responsible for the synthesis of this substance into fungi. The structure of the borrowed DNA segments was optimized to increase the intensity of synthesis by approximately 100-fold. The authors hope that this will make it possible to significantly increase the production of preparations based on orcin glycosides.
Depression is considered one of the most pressing problems of the modern world, and the effectiveness of traditional antidepressants is low. Also, many of them are addictive or have side effects. Orsin glycoside is one of the promising plant analogues of synthetic antidepressants.
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Source: Gazeta
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