Scientists have developed a three-dimensional structural model of the human hippocampus. In this respect informs The Human Brain Project portal.
The resolution of the model makes it possible to distinguish individual cells, as well as reproduce the structure and architecture of this area of the brain, its location in it and neural connections. The model was obtained by synthesizing multiple brain images, and according to the authors, the same methodology can be applied to create full-scale models of other areas of the human brain.
“The amount of data on individual neurons in the human brain is very limited, both in terms of relative three-dimensional coordinates and communication between neurons,” explains Michele Migliore, one of the authors of the study. “We data-mined high-resolution images of the human hippocampus from the BigBrain database. The position of individual neurons was determined by detailed analysis of these images.”
The researchers developed their own image processing algorithms to determine the true spatial distribution of neurons, and an algorithm to detect neuron connectivity by approximating (approximating) the shape of dendrites and axons.
“Dendrites and axons can be categorized by the shape of their processes: for example, some fit into narrow cones, others have a complex extension whose shape can be described by a series of geometric shapes and connections with neighboring neurons. It depends on this shape,” explains Daniela Gandolfi. creates a set and calculates the probability that two neurons are connected.
The authors hope their model will help scientists explore the structure of the brain.
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Source: Gazeta
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