Researchers at the Perm National Research Polytechnic University (PNRPU) have unveiled a new topical ointment designed to treat burns, wounds, and abrasions. The development centers on albumin, a primary protein found in blood plasma, and the details were shared with socialbites.ca by the university’s press service.
The team examined the albumin-based composition of the only commercially available remedy of this type and pinpointed its drawbacks, notably the difficulty in producing and using an alcohol extract. This limitation made the existing formulation unsuitable for open skin lesions, where direct contact with underlying tissues is necessary for effective healing.
To address these issues, researchers devised a new formulation that uses a 20% solution of human albumin. Owing to its high binding capacity, albumin serves as the main carrier for a variety of molecules, including drug particles, ensuring that active ingredients reach the wound site efficiently. In addition, albumin is known to promote healing when applied topically, a property the team leveraged in their new preparation.
The base of the ointment was engineered from stearic acid, polysorbate 80, glycerin, and potassium carbonate, with the incorporation of silver citrate serving as a protective and disinfecting element. This combination aims to maintain stability during storage while contributing antimicrobial protection at the wound surface.
In describing their iterative process, the researchers noted that multiple formulations were tested by tweaking both the production steps and the ingredient ratios. Trials demonstrated that the resulting compositions conform to the State Pharmacopoeia of the Russian Federation for external dosage forms and ensure effective interaction of the active substance with the wound surface, providing a consistent delivery of albumin to damaged tissue. The team member speaking on the project emphasized that the approach balances efficacy with safety and aligns with established pharmaceutical standards. (Source: Perm National Research Polytechnic University)
A key finding highlighted that the main and auxiliary components remain integrated throughout production and transportation, preventing separation that could reduce effectiveness. The drug also retains its properties during extended storage and can be applied directly to burns and cuts due to the absence of alcohol in its formulation, a feature that reduces irritation risks for sensitive skin. This stability and user-friendly aspect are viewed as advantageous for use in clinical settings and by individuals seeking at-home care for minor injuries. (Source: Perm National Research Polytechnic University)
Beyond the Perm team, other Russian researchers have explored related vascular repair approaches, offering insights into how patient-derived cells might contribute to tissue healing in broader medical contexts. Such lines of inquiry help frame the ongoing work on albumin-based topical therapies within the wider landscape of regenerative medicine and wound management. (Source: Perm National Research Polytechnic University)