UC Davis (US dollars aside) announced a new phase in testing a hormonal gel designed for men as a form of birth control. The project is centered on offering a reversible, well-tolerated option that mirrors the core idea of hormonal contraception used by women, but with a formulation tailored to male biology and everyday needs. The effort reflects ongoing work to broaden male-centered options for family planning and to support shared responsibility in consent-based decisions.
The gel, intended for application to the shoulders, delivers two hormones, progestin and estrogen, to regulate reproductive processes. In men, the formulation focuses on a progestin called Nesterone, which suppresses sperm production while preserving normal testosterone levels. This approach aims to reduce the chance of pregnancy without causing broad hormonal suppression that could affect energy or mood in daily life. The design seeks a balance between effectiveness and a favorable safety profile for long-term use.
Reported side effects among participants have included changes in skin texture such as dry or oily skin, shifts in libido, hair growth or shedding, and mood fluctuations. In a California trial, one participant experienced minor weight gain along with an increase in sexual desire. The range of responses highlights the need for ongoing monitoring and personalized dosing and management during broader trials.
Researchers note that the gel may deliver results that are comparable to or exceed some female regimens, while not simply duplicating them. The findings point to a reliable, reversible method to restore fertility after discontinuing the gel, typically within several months. Reversibility is a key factor for participants and those evaluating the overall risk-benefit profile of such a method. The research team emphasizes informed consent, regular medical review, and clear communication about expectations as trials progress.
Clinical trials have entered the second or near-final phase and involve multiple centers around the world. At UC Davis and other international sites, researchers have continued the study for several years, aiming to confirm long-term safety, consistency of results, and practical considerations for real-world use. The collaborative nature of the work helps gather diverse data on how different populations respond to the gel, supporting a comprehensive assessment of efficacy, tolerance, and potential impact on daily life.
Earlier reports from participating scientists highlighted lessons learned about hormonal delivery, dosing regimens, and monitoring requirements. The team continues to refine protocols to minimize skin reactions and mood-related side effects while preserving the contraceptive effect. As trials expand, participants receive ongoing evaluations to ensure that any adverse effects are detected promptly and managed effectively. The ultimate aim is to offer a dependable, user-friendly option that expands autonomy over reproductive choices for men, couples, and healthcare providers alike.