Researchers from a major medical center reported that lymphedema affecting the legs roughly doubles the risk of developing several forms of skin cancer. The findings appeared in Mayo Clinic Proceedings.
In this study, investigators evaluated data from 4,437 individuals diagnosed with lower-limb lymphedema. Compared with a control group without the condition, there was a higher incidence of basal cell carcinoma and squamous cell carcinoma. Some participants had lymphedema in only one leg, and those with the affected limb showed nearly three times the chance of skin cancer on that limb compared with the healthy leg.
Lymphedema is a persistent swelling of soft tissues caused by disrupted lymphatic drainage. It can arise after surgeries or cancer treatments that remove or impair lymph nodes. In rarer cases, hereditary conditions can lead to lymphedema. Historically, the condition has been linked to a greater likelihood of dermatitis, trophic ulcers, and other skin disorders. The authors emphasize that individuals with lymphedema should undergo regular dermatological checkups to spot cancer at an early stage, improving treatment outcomes [1].
Awareness remains important: early detection through routine skin examinations and prompt evaluation of suspicious lesions can significantly impact prognosis. Healthcare providers are encouraged to educate patients about self-monitoring and the signs of skin cancer that might arise in affected limbs. The study aligns with broader efforts to understand how lymphatic disruption affects cancer risk and underscores the value of ongoing surveillance for this population [2].
In clinical practice, patients with lower-limb lymphedema may benefit from a multidisciplinary approach, including dermatology, oncology, and physical medicine, to manage swelling and monitor skin health. As research continues, clinicians advocate for personalized plans that address both lymphatic symptoms and cancer risk, with attention to limb-specific changes and patient education. Such strategies aim to improve long-term outcomes and quality of life for those living with lymphedema [3].
Note: The reported associations are observational and do not prove causation. Nonetheless, they highlight a meaningful link between limb edema and skin cancer risk, reinforcing the importance of vigilant skin care and professional assessment for affected individuals [4].