Researchers from RIKEN have unveiled a breakthrough approach that enables drug molecules to be synthesized directly inside a patient’s body. In studies conducted on animals, this method demonstrated strong therapeutic potential, and the findings were published in the scientific journal Chemical Science, offering a fresh perspective on targeted drug delivery. (citation: Chemical Science, 2023)
Traditional medicines, whether given by injection or in pill form, circulate through the bloodstream and interact with both diseased targets and healthy tissues. This broad distribution can lead to unwanted side effects that are severe enough to interrupt treatment or compromise overall health. The new approach emphasizes precise placement of medications within the body, aiming to reduce collateral damage and improve tolerability for patients. (citation: Chemical Science)
The core chemistry centers on a catalytic process known as olefin metathesis, which enables the formation of specific carbon–carbon double bonds essential for the desired drug structure. Through controlled reactions, researchers can steer the synthesis to produce therapeutically active compounds at the target site, potentially lowering systemic exposure and enhancing efficacy. (citation: Chemical Science)
To overcome a common hurdle—rapid inactivation of chemical catalysts in blood—scientists introduced a ruthenium chloride catalyst into a protective protein layer formed by human albumin. This protective envelop helps shield the catalyst, allowing it to function in the body without being quickly deactivated, thereby enabling the intended biochemical transformation in real time. (citation: Chemical Science)
Early experiments with this strategy showed that administering low doses could significantly hinder tumor growth in animal models by triggering inhibitory molecular pathways within the tumor environment. The results highlight the potential for in-body synthesis to achieve concentrated, localized drug activity while minimizing damage to healthy tissues. (citation: Chemical Science)
As a point of reference, researchers have previously explored therapies that leverage beneficial bacteria to reduce cancer risk in the bowel, underscoring a broader interest in innovative, biology-conscious treatment strategies. This lineage of work reflects a growing emphasis on precision medicine, where the goal is to maximize therapeutic benefits while curbing adverse effects through smarter delivery and design. (citation: Chemical Science)