As part of the research team, scientists from the Stowers Institute for Medical Research discovered that a particular gene, slc27a2a, protects fish from the Astyanax mexicanus species from fatty liver disease. Research results published In the journal Life Science Alliance (LSA).
It is stated that the most common causes of fatty liver disease in humans are malnutrition, alcohol use, taking certain medications and metabolic syndrome (obesity and diabetes). In fatty liver disease, fat-like substances, medically called lipids, accumulate in the organ structure. Lipid accumulation can occur due to both overeating and fasting.
Scientists studying the fish Astyanax mexicanus discovered that representatives of this species have reduced expression of a special slc27a2a gene. Astyanax mexicanus is a freshwater ray-finned fish from the characin family, native to the Americas and Mexico. It has no eyes or any pigment color. Scientists found that slc27a2a deficiency allows fish to remain resistant to starvation and not accumulate fat in the liver.
It is stated that fat accumulation in liver cells causes organ damage and increases the risk of developing cirrhosis (proliferation of connective tissue and functional failure). Reducing slc27a2a activity in humans may protect the liver from the harmful effects of lipids, scientists say. Additional research is needed to uncover the therapeutic potential of this mechanism.
Previously in the USA approved The first medicine against “fatty liver”.