The GDF15 hormone produced by the fetus causes nausea and vomiting in pregnant women, which in some cases can threaten the life of the woman and the unborn child. Giving women hormones before pregnancy can relieve nausea, according to a study published in the journal. Nature to work.
80% of women suffer from nausea and vomiting at some stage of pregnancy, and another 2% have a severe form – hyperemesis gravidarum. This condition can lead to weight loss, dehydration, and hospitalization.
A new study found a causal link between high levels of the hormone GDF15 and the severity of nausea in pregnant women. Women with mutations that increase hormone sensitivity experience more severe symptoms. However, if the fetus inherits a mutation that reduces production of the GDF15 hormone, the mother may be less likely to develop hyperemesis.
Scientists have also found that patients with the inherited blood disease beta thalassemia are much less likely to suffer from nausea and vomiting during pregnancy. This is because they have chronically high levels of GDF15, meaning their body gets used to it.
Studies in female mice have shown that administering GDF15 at low concentrations allows animals to develop sensitivity to it and prevent nausea and vomiting even with high doses of the hormone. Scientists plan to test this approach on women who experience hyperemesis and are planning a new pregnancy. Drugs that block GDF15 from binding to its receptor in the brain are also currently being tested. It is planned to be used in patients suffering from nausea and vomiting due to cancer treatment.
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