A new study by scientists at the University of Tsukuba in Japan found that trigonelline (TG), a plant compound found in coffee, significantly improved spatial learning and memory in aged mice. results published on SpringerLink.
Scientists are focusing on finding natural compounds that may prevent age-related cognitive decline and promote healthy aging. Researchers have suggested that trigonelline (TG), a plant substance found in coffee and some vegetables, may have this effect.
To test whether this is true, scientists conducted an experiment on old mice. The rodents were divided into two groups; The first group was administered oral TG for 30 days, and the second group served as a control. At the end of the experiment, scientists evaluated the cognitive abilities of all the mice. The results showed that the rodents in the first group coped better with the tests than their relatives in the control group.
Trigonelline was able to stimulate mitochondrial function and ATP synthesis. Mitochondria are called intracellular energy stations. As the body ages, mitochondria function less well and are unable to effectively produce ATP, an organic compound that serves as the main energy source for cells. Age-related mitochondrial dysfunction leaves neurons vulnerable, leading to symptoms such as memory loss.
In addition, the research team found that TG suppressed neuroinflammation (inflammation that occurs in nerve tissue in response to bacterial and viral infections, head injuries, and exposure to toxins). Neuroinflammation is a key feature of Alzheimer’s disease.
existed before named Beverages that may increase the risk of dementia.