Researchers from Belgium took an important step in understanding the early illness of Alzheimer, a rare hereditary variant of the disease, which began at a relatively young age. Some genetic mutations have found that the disease can “operate ında in a certain life life like a biological clock. Published in İş Magazine Molecular Neurodegeneration (MN).
Alzheimer’s disease is one of the most complex and common neurodegenerative diseases that affect approximately 50 million people in the world. The exact causes are still not fully understood, but it is known that special protein accumulation of amyloid plaques – patients’ brain has accumulated.
Alzheimer’s early illness is the form of a rare disease that begins at a hereditary and early age. Until recently, doctors could not correctly evaluate how specific mutations affected the development of the disease.
Scientists examined three gene associated with the development of the disease: App, psen1 and psen2. It turned out that different mutations in these genes affect the age that a person will begin to reveal the first symptoms – memory deterioration, confusion of thoughts and other dementia symptoms.
The authors of the study developed a special model that allows you to in advance how dangerous this or mutation was and when the disease could begin. In addition, if you change the proportion of certain proteins in the brain, the development of the disease can be postponed for several years.
This discovery will help doctors more accurately diagnose Alzheimer’s disease and choose the right treatment methods. In the future, scientists hope to develop drugs that will slow down the development of the disease before the start of symptoms.
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Source: Gazeta
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