San Antonio et al. University of Arkansas Duke University, Texas University, developed a way to significantly improve the penetration of promising anti-cancer drugs into cells. Published in İş Magazine Cell.
We are talking about the preparations of the protactor class – complex and voluminous molecules that destroy proteins in the cells and are accepted as a promising direction in the treatment of cancer. However, due to large dimension, it is difficult to penetrate these substances from the cell membranes. The new strategy has made it possible to increase its purchases by 7.7-22.3 times and increase the effectiveness of the action to 23 times.
The key role is played by the CD36 protein on the surface of the cells. It is included in the endocytosis process – “swallowing” molecules with a cell. Scientists have changed their protacac molecules more actively with CD36, so it is easier for drugs to enter. The new approach was called chemical endocytic medical chemistry.
“This discovery may breathe a new breath for many medicines that have not been suitable before, Düzen this discovery can breathe a new breath before the weak absorption.
Observations on mice show that drugs with a new modification did not only penetrate the cells better, but also enabled tumor growth to be more pronounced. In addition, these results were independently reproduced in the three scientific centers participating in the study.
Although the data obtained is impressive, the method needs a clinical control. However, scientists are sure: potential goes far beyond oncology. Technology can pave the way for creating effective drugs for many diseases, including neurodegenerative and autoimmune.
Previously, scientists To create A way to stop dangerous blood mutations associated with aging.
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Source: Gazeta
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