Scientists of the Biotechnology Company Akero Therapeutics have developed an experimental drug efruxifermin that can rotate liver cirrhosis with metabolic -related steatogepatitis. According to Akero experts, they succeeded. The drug was already tested on volunteers. The work lasted 96 weeks and An improvement was recorded in 39% of patients with 50 mg medication – The cirrhosis of the liver began to decline. A similar effect was observed in only 15% of the participants in the placebo group.
“It is important to state that liver cirrhosis is a complex clinical and laboratory diagnosis that the liver can no longer function. That is, according to elastometry, you can diagnose the F3-F4 fibrosis stage on the metavir scale, but if the liver is processed, there will be no cirrhosis. However, it is important to capture the moment when the line is very thin and the liver does not lead to cirrhosis. The development of the cirrhosis of the liver is of course a long process that can lead to a metabolic -related liver disease. In addition, fiber nodes can lead to cancer formation when they are reborn into cancer cells. ” Acad. BV Petrovsky Elizabeth Sidorov.
Nuance is that different causes can lead to liver fibrosis and according to them, doctors choose treatment. For example, the death of hepatocytes can cause alcohol, hepatitis B and C viruses as well as metabolic-related liver disease (meta-EBP). The important thing is the formation of metabolic -related steatogepatitis (MASH). This situation emerges as a rule, People overweight, cardiovascular diseases and diabetes. He is called to reject the new medicine.
The main aspect of the treatment of metabolic -related fatty liver disease is a lifestyle change. Drug therapy of this pathology includes medications to overcome insulin resistance, omega-3-pink, statins, fibrats, hepatoprotectors.
According to Sidorova, efruxifymin was developed to simulate the biological activity of the growth factor of Fibroblast 21 (FGF21), which regulates many metabolic roads and cell processes. Efruxifermin, which provides sustainable and balanced transmission of signals through FGF21 receptors in liver and adipose tissue, can be used for mashed treatment affecting all the main factors of the progression of the disease.
“Advanced drug helps to decline cirrhosis, but it cannot refuse as many people understand. However, we increase fat metabolism and reduce toxicity for the liver. Oil is processed and discarded from the body, which ultimately reduces the negative effect on hepatocytes. The disappearance of cirrhosis observed according to the results of histological studies as a part of the study was confirmed by improving non -invasive indicators of fibrosis and liver damage. If there were fibrosis in the fourth stage, it may go to the third or second stage. But not the fact that the liver will be completely healthy, El Elizabeth Sidorova explained.
Therapist, gastroenterologist, medical practitioner JSC (Academian Roitberg Clinic), Professor Rnimu took the name Pirogova Olga Sharkhun In most cases, the cirrhosis of the liver can be reversed due to the presence of fibrous changes in the liver tissue.
“Fibrosis is the process of changing the healthy connective tissue, which is usually irreversible. However, the modern medicine process gives the chance to slow down and improve the quality of life with changes and change in lifestyle. In some cases, especially if the patient rotates in early stages, you can see the regression of fibrosis with adequate antiviral treatment or eliminate the effects of toxins. However, with the return of the liver to a healthy hepatocyte of all cells, it is impossible to fully restoration, and the purpose of the treatment is to maintain the function of the liver and to improve the patient’s condition. ”
According to him, Cirrhosis is not treated in cases where the disease is in the terminal stage and there are serious complications. Severe liver encephalopathy, acid, bleeding or infectious complications. At this stage, there are already irreversible liver changes and the only option for treatment can be transplant.
It is also important to remember that the advanced drug helps only one cirrhosis, which is a metabolic -related steatoPatitis. For example, With alcoholic cirrhosis, this medication will not help.
In the first stages of the disease, etiological treatment aimed at eliminating the cause of cirrhosis – in the case of alcoholic cirrhosis – this, completely rejection of alcohol, eliminating other toxic factors, viral nature of the disease, viral nature of the disease, the prescription of antiviral treatment will be effective, autoimmune hepatitis, glucocorticosteroids treatment treatment treatment prescribed. The treatment of liver cirrhosis is performed extensively, treatment is developed individually depending on the dominance of some clinical syndromes and taking into account the complications of the disease. ”
He stressed that hepatoprotectors were ineffective during the cirrhosis stage.
“Due to fat and carbohydrates due to adequate calorie content, dietary fibers, vitamins and work elements to the diet of the animal proteins are subject to a diet with the correction of salt is very important,” he said.
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Source: Gazeta
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