New genetic risk factors for intervertebral hernia found 18:11

Scientists from the University of Oulu (Finland) have discovered 41 new regions of the genome that affect the risk of developing intervertebral disc herniation. They are very close to the genes responsible for inflammation. Research results It was published In the journal Nature Communications (NatCom).

A herniated disc is the most common cause of low back pain, which often requires surgical treatment. This pathology is characterized by the protrusion of part of the intervertebral disc through the space between the vertebral bodies. Such formations can put pressure on nerve structures and other tissues, causing pain during exercise and at rest, numbness and loss of sensation in the limbs.

Risk factors that can trigger the occurrence of intervertebral hernia include overload, injury, poor posture, excess weight and developmental abnormalities. The role of genetic factors in intervertebral disc degeneration has been identified relatively recently. Science already knows that 23 genomic regions can influence the risk of pathology.

In a new study of the genetic data and health of 829,699 volunteers, researchers identified 41 additional areas that determine the likelihood of a herniated disc. The scientific team determined that the discovered areas were located close to genes that regulate inflammation and synaptic transmission of nerve impulses.

Five new genomic regions were associated with severe pathology requiring surgical intervention. Genes that affect the duration and intensity of back pain have also been identified.

Scientists noted that the findings and data sets could be used to develop medical and preventive solutions in the future. For example, genetic data on pain severity may be useful in creating analgesics for patients with herniated discs.

Previously named Gentle exercises to relieve back pain.