A team led by Associate Professor Kristin Allin from Aalborg University in Copenhagen found that carrying the HLA-DRB*01:03 genetic variant significantly increases the risk of developing severe forms of ulcerative colitis that require surgery. The results of the study were: It was published In JAMA (Journal of the American Medical Association).
Scientists analyzed more than 9.5 million genetic variations in more than 4,500 patients with ulcerative colitis. This is a chronic, relapsing disease of the colon, characterized by pain and the formation of ulcers on the mucous membranes.
The HLA-DRB*01:03 variant in the genes of the major histocompatibility complex (located on chromosome six) has been found to play a key role in the development of severe forms of the disease and its complications.
Scientists estimate that this unwanted variant increases the risk of developing severe ulcerative colitis by 3.32 times. It also increases the likelihood of needing complex surgery by six times and the risk of re-hospitalization by five times.
Previously found A new bacteria that causes immune deficiency in the intestine.
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Source: Gazeta
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