The accumulation of lipids (fats) stimulates the aging of dopaminergic nerve cells in the brain, and their dysfunction is associated with Parkinson’s disease. This was demonstrated in a study published in the journal Neurology. Aging.
Parkinson’s disease is a movement disorder that is specific to the elderly and is associated with the loss of dopaminergic neurons. At the same time, dopamine production in the brain decreases and therefore treatment methods aim to restore its levels. However, the underlying causes of dopaminergic neuron loss are unknown. Therefore, there is no effective way to prevent or slow down the disease.
In the new study, scientists artificially induced lipid accumulation in dopaminergic neurons. This accelerated their cellular aging and caused cell loss. They also found that the activity of the gene responsible for the production of perilipin, a protein associated with lipid droplets, was increased. The scientists believe that drugs targeting this molecule could be a valuable tool in the fight against Parkinson’s disease.
Formerly a doctor It has been saidwhen brain aging begins.
Source: Gazeta

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