Scientists from the University of Leeds and the University of Lancaster, both in England, found that blocking the activity of the PDE4B enzyme may protect against Alzheimer’s disease by reducing inflammation in the brain. Research results published In the journal Neuropsychopharmacology (NPP).
The gene that regulates the PDE4B enzyme of the same name has previously been identified in the scientific community as a risk factor for the development of Alzheimer’s disease. The PDE4B enzyme breaks down a molecule known as cyclic AMP. It is a second messenger required for intracellular signaling of a number of hormones.
In a new study involving laboratory mice with Alzheimer’s disease, scientists observed that rodents with genetically reduced PDE4B activity did not experience memory impairment. Using functional brain imaging, the team found that this trait is associated with healthy glucose metabolism in the brain. Glucose is the main energy source that ensures the functioning of the organ.
It was also found that reducing PDE4B activity helps suppress inflammation in the brain, thus preventing the onset of cognitive impairment. Scientists estimate that reducing enzyme activity by 27% in mice with Alzheimer’s disease significantly improved memory and attention.
Drugs that inhibit PDE4B may be potentially effective in preventing and treating this neurodegenerative disease, the researchers said.
Russian scientists before to create A new approach to the treatment of neurodegenerative diseases.
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Source: Gazeta
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