Doctors have identified symptoms of a dangerous VEXAS disease that affects people over 50 Health: 47% of people live less than five years after being diagnosed with a new VEXAS disease 20:57

Vexas syndrome, discovered by scientists in 2020, causes painful rashes and inflammation in blood vessels, lungs, joints and skin. The disease affects men more Health.

VEXAS syndrome is an inflammatory disease that primarily affects the bone marrow and blood. The disease was first detected at the end of 2020. It usually causes painful rashes and inflammation in the blood vessels, lungs, joints, and skin.

VEXAS is an abbreviation that refers to the basic features of the syndrome. The disease can be detected by altered vacuoles (V) in bone marrow cells. The syndrome results from the breakdown of the E1 (E) protein due to mutation in the UBA1 gene on the X chromosome (X). As a result, an autoimmune reaction (A) develops, meaning the immune system attacks healthy cells. In this case, the mutation is somatic (S), meaning it is not inherited, but occurs in adults.

VEXAS syndrome is difficult to diagnose because it has a wide range of nonspecific symptoms that are also found in other diseases. The disease is known to cause cough, fever, pain and swelling in the ears, nose and joints, painful rash, fatigue and shortness of breath.

Studies have shown that VEXAS syndrome mainly affects men over the age of 50. This is because women have only one X chromosome, while women have two. If one copy of the UBA1 gene is damaged on one chromosome, women have a “spare” gene on their second X chromosome.

Many people with VEXAS syndrome take anti-inflammatory medications, glucocorticoids, to relieve symptoms. One promising treatment is a bone marrow transplant, which allows the person to produce normal blood cells. However, it also brings significant health risks. If left untreated, the disease can cause anemia, blood clots and blood cancer.

VEXAS syndrome has a high mortality rate; Only 53% of patients survive five years after diagnosis. Studies have shown that life expectancy may depend on the type of mutation.

Previous scientists reportedIt is stated that smokers over the age of 50 can reduce the risk of lung cancer by 39%.