At the Ryazan State Medical University named after him. Pavlov developed a casting mold and hydrogels using cells from the patient’s vessel wall to create three-dimensional models of blood vessels. These models will then be used for implantation in the treatment of atherosclerosis. This issue was reported to socialbites.ca by III. It was explained at the press center of the university technological entrepreneurship platform of the Ministry of Education and Science of the Russian Federation within the framework of the Congress of Young Scientists.
“The form we have developed is designed in such a way that there is a cavity inside, the contours of which correspond to, for example, the human carotid artery. A biopolymer gel that we have developed on a polysaccharide-protein basis is poured into it, and into it we pre-insert the patient’s cells, in particular fibroblasts, smooth muscle cells and endothelial cells. Then, for an hour polymerization occurs in it and we get a finished model of the ship,” Alexander Zakharov, one of the authors of the project, told socialbites.ca.
Today, artificial vascular prostheses, autografts and shunts are used in the treatment of atherosclerosis in vascular surgery, but these have some disadvantages and cannot completely replace the vessel. Therefore, shunts are subject to occlusion (clogging) within five years of installation, and vessels can cause microbleeds due to their porous structure.
3D printed casting molds make it possible to create vessel models free of these drawbacks: they fully perform their functions and are not susceptible to clogging.
“Our development uses patient cells; this is personalized medicine. This solves the problem of implant rejection due to incompatibility of the cellular material. In addition, vascular implants on the market have a porous structure. This is also a minus because platelets can accumulate in the pores. No in our time, they completely copy the texture of real vessels. In the future “We plan to use stem cells that we will isolate from the patient’s blood and transform them into mature cells.” explained Zakharov.
The team is currently conducting in vitro studies to evaluate the compatibility and toxicity of the hydrogels for vascular applications. So far the results are positive, but the work is not done yet. Experiments on animals are planned in the future.
Formerly at the Petrovsky Artist Research Center in the name Five diseases that can be treated with medicine obtained from patients’ oils.
Source: Gazeta
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