Scientists from the Salk Institute have discovered that time-limited eating changes the activity of mice’s genes by synchronizing the biological clocks of various body systems. The research was published in the journal Cell Metabolism.
Numerous studies have shown the benefits of intermittent fasting for the treatment of obesity, diabetes, and other diseases. The time-restricted diet also extended the lifespan of the mice in the lab. However, the effects of such nutrition at the molecular level are still poorly understood.
In the new study, two groups of mice were fed the same high-calorie diet for seven weeks. One group provided free access to food and the second only nine hours a day. Next, the scientists analyzed the activity of genes in 22 organ groups (stomach, kidneys, lungs, heart and others) and in the brains of the animals.
Overall, 70% of mouse genes altered their activity, including in the brain. Almost 40% of genes in the adrenal, hypothalamus, and pancreas have altered their activity. These organs are important for hormonal regulation, the disorders of which are associated with diabetes and mental disorders.
The researchers also found that time-limited eating synchronized the biological clocks of different organ systems. A previous study by scientists has shown that time-restricted meals improve the health of firefighters who typically work shifts and therefore suffer from jet lag.
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Source: Gazeta
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