Rush University neuroscientists have uncovered the structure of the body system that detoxifies the human brain. Study published in the Journal of Experimental Medicine.
Researchers have studied the brain’s lymphatic system. As it leaves the brain, the toxic fluid is transported to the arachnoid granulations. These are small convex formations of the arachnoid membrane of the brain, protruding from the hard shell and participating in the circulation of the cerebrospinal fluid. Through the granulation of the arachnoid, the cerebrospinal fluid exits the subarachnoid space into the sinuses of the dura mater and mixes with the main blood flow.
The team analyzed more than 400 granulations in multiple brain samples. The researchers found that a significant proportion of granulations limit the bone and lymphatic ducts, not the great vessels of the brain, as assumed in previous studies.
Scientists have also found that the internal structure of the granulations consists of fragments of collagen that form a fine spongy network and contain various immune cells, and the outer capsules of the granulations are perforated.
The structure of the granulations suggests that the fluid, along with the toxins, seeps through the spongy tissues and enters the other meninges, where the lymphatic vessels and bones are located.
“For hundreds of years they were considered passive tissues, and the meninges were considered membrane-enclosed seals. This region of the brain is rarely analyzed and is not considered in a brain autopsy. Given that arachnoid granulations undergo significant age-related changes, this makes them brain like Alzheimer’s disease. may indicate its role in their disease,” he said.
Source: Gazeta
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