Researchers at North Carolina State University in the United States have created a flexible electronic patch that uses microneedles to deliver a range of drugs without pain. The work appears in the scientific journal Nat Comms.
The device, called the Spatiotemporal On-Demand Patch, or SOP, is a compact polymer plate covered with many tiny drug-filled spikes. When applied to the skin, the spikes gently pierce the outer skin layer without causing discomfort.
SOP stands out from other microneedle patches thanks to its built in electrical circuitry. This system lets the spikes be activated individually to dispense different medications. Activation can be controlled from a smartphone or computer. Once a signal is received, the device heats the chosen elements, dissolves them, and releases the drugs within about 30 seconds. [Citation: NatComms]
In laboratory testing, the patch successfully delivered multiple doses of melatonin to mice, showing the potential to support healthy sleep patterns through painless administration. [Citation: NatComms]
The scientists envision applying this technology to chronic conditions such as Alzheimer disease by programming the patch to automatically deliver medication on a schedule. They note that the device can be loaded with dozens or even hundreds of doses for long term treatment. [Citation: NatComms]
Earlier research has already shown smart insulin delivery systems that reduce the number of injections needed for diabetes management, illustrating a broader push toward programmable, patient friendly therapies. [Citation: NatComms]