Elevated blood pressure and high LDL cholesterol during youth and middle age are linked to a greater risk of heart disease later in life. This finding comes from researchers at the George Institute for Global Health, a multidisciplinary science hub with campuses in Australia, China, India, and the United Kingdom, who published their results in PLOS One [Citation: George Institute for Global Health].
In the study, participants were organized into three cohorts. A total of 136,648 individuals underwent blood tests to measure low-density lipoprotein (LDL) levels, 135,431 had their systolic blood pressure (SBP) recorded, and 24,052 received screening for coronary artery disease. The researchers explored how elevated blood pressure, high LDL cholesterol, and early ischemic indicators in people under 55 relate to the lifelong risk of cardiovascular disease.
The analysis demonstrated that higher SBP and LDL levels correspond with an increased probability of developing heart disease over time. Remarkably, even when these indicators decline later in life, the elevated risk persists, underscoring the long-term impact of midlife risk factors on heart health [Citation: George Institute for Global Health].
The study authors stressed the importance of ongoing monitoring of cardiovascular risk factors starting in young and middle age. They noted that blood pressure can be influenced positively through lifestyle choices such as balanced nutrition, weight management, reducing sodium intake, and regular physical activity. Natural strategies to support healthier LDL levels include adequate intake of micronutrients and fats from fish, as well as plant sterols found in certain fortified foods and plant-based products [Citation: George Institute for Global Health]. The researchers emphasized that these approaches can contribute to better vascular health over the lifespan, complementing medical guidance when necessary.
Earlier findings in related analyses have linked higher birth weight with increased risks for childhood obesity, illustrating how early life factors can foreshadow later cardiovascular trajectories. These connections highlight the importance of preventive care and early lifestyle interventions for long-term heart health [Citation: George Institute for Global Health].
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