Older women with type 2 diabetes show higher bone density yet face more fractures
Recent research published in Nature reveals a surprising pattern among older women living with type 2 diabetes. Despite having higher bone mineral density and improved bone microstructure in multiple body regions, these women experience a higher rate of fractures over time. This finding challenges the assumption that stronger bones alone reduce fracture risk. The study highlights a nuanced relationship between bone health markers and actual fracture outcomes in this population. [Nature study, 2024]
A large, age focused comparison was conducted with 3,000 women diagnosed with type 2 diabetes matched to 3,000 healthy peers. All participants were within the range of 75 to 80 years old. The data collection spanned several years, offering a long view of how bone health and fracture risk evolve in late life. [Nature study, 2024]
In all measured regions, bone mineral density was higher for the diabetes group. Bone microarchitecture also appeared more robust in these women. Yet no difference emerged in the bone strength index between the two groups, suggesting that density and microstructure alone do not fully explain fracture risk. [Nature study, 2024]
On the functional side, the group with type 2 diabetes performed worse on several physical function tests. Grip strength, walking speed, and the ability to rise from a chair were notably reduced compared with peers without diabetes. These functional limitations likely contribute to a greater chance of falls and fractures. [Nature study, 2024]
Participants were followed for roughly seven years. Across all fracture types, rates were higher among women with type 2 diabetes. The authors propose that diminished physical function may help explain why the fracture risk remains elevated despite higher bone density. [Nature study, 2024]
Fractures in older adults carry serious consequences. Healing after fracture tends to be slower and less complete, with femur fractures in particular associated with reduced quality of life and elevated mortality risk. The study offers important context for clinicians and caregivers seeking to reduce fracture risk in older patients with diabetes. [Nature study, 2024]
In related findings, earlier work has shown that dietary interventions with meal replacements can influence diabetes outcomes. Some individuals have achieved remission through structured dietary changes, underscoring the potential for lifestyle strategies to complement medical care. [Nature study, 2024]