Scientists at Ben-Gurion University in the Negev have explored a promising natural molecule, 3,3′-diindolylmethane, also known as DIM or bisindole, for dental care. The researchers examined how adding this compound to toothpaste and mouthwash might influence the formation of dental plaque and the development of cavities. The work is reported in the scientific literature on antibiotics, shedding light on potential preventive strategies for everyday oral health in North American settings as well as internationally.
In laboratory assessments using microbial cultures, the team observed that DIM reduced bacterial biofilms by up to nine tenths in certain tests. This molecule is produced naturally in the body from compounds found in cruciferous vegetables, and it has long been studied for various biological activities. In the mouth, the biofilm in question is a complex community that, when unchecked, contributes to the wear of enamel, the emergence of plaque, and ultimately caries. The reduction of this biofilm signals a potential pathway to limit harmful bacterial growth without relying solely on conventional antiseptics.
Beyond its effects on oral bacteria, DIM has attracted interest for other biological properties, including anti-cancer activity demonstrated in several laboratory studies. The current findings indicate that DIM exhibits relatively low toxicity in preclinical contexts, which supports further exploration of its safe integration into everyday dental products for people in North America and beyond. When incorporated into toothpaste and mouthwash formulations, this molecule could become part of a broader approach to maintaining oral health while maintaining product safety and consumer acceptability.
The research was conducted by scientists from Ben-Gurion University of the Negev and included collaborators from the University of Sichuan and the National University of Singapore. The study’s aims emphasize practical applications for consumer health products, focusing on how a naturally occurring compound might contribute to reducing biofilm-related dental issues and supporting routine oral hygiene practices suitable for diverse populations in Canada and the United States.
As with any new ingredient added to consumer care products, ongoing studies are expected to address long-term safety, interactions with standard oral care routines, and the general effectiveness of DIM in real-world use. The consensus among researchers is that while initial results are encouraging, comprehensive clinical trials and regulatory review will shape how widely such ingredients might be adopted in over-the-counter products and professional dental care recommendations in North America.