Researchers from the Institute of Computational Mathematics at the Russian Academy of Sciences, in collaboration with European colleagues, have identified a link between chronic viral infections and the premature loss of macrophages. This early macrophage decline disrupts the production of antiviral interferon proteins, allowing pathogens to persist in the body. The finding was reported by TASS, citing the Russian Science Foundation as backing for the work.
In controlled experiments with rodents infected by the LCMV virus, which is known to cause lymphocytic choriomeningitis, the data revealed a distinct pattern. During acute infection, the organism generates two sequential waves of antiviral interferon. In contrast, chronic infection elicits only a single interferon wave, a consequence of macrophage death in the spleen that normally drives the second wave. This observation suggests a coordinated failure in immune signaling that accompanies prolonged viral presence.
The researchers propose that a comparable mechanism may operate in humans, offering a possible explanation for why some chronic viral infections resist clearance. Looking ahead, the team aims to uncover the triggers behind macrophage loss and to develop initial strategies that could block this process. Such advances would help preserve molecules critical for immune defense and improve the body’s ability to respond to persistent infections.
In related developments, prior studies have explored promising avenues for dementia treatment. While progress has been incremental, ongoing investigations continue to test new approaches that could eventually translate into meaningful clinical options for patients.