As people taking Ozempic lose weight, their muscle mass decreases. However, this process is natural and occurs because the muscles experience less stress when losing weight. This is shown by the study published in the journal. Circulation.
Recent studies show that GLP-1 agonist drugs (Ozempic and its analogues) lead to almost the same weight loss as gastric sleeve surgery. However, rapid weight loss can cause muscle loss.
In a new study, scientists from the University of Tübingen found that GLP-1 agonists lead to a decrease in muscle mass. However, this process is natural: Losing weight causes less strain on the muscles. This reduces their mass. A similar process occurs in the heart when treating hypertension: Lowering blood pressure allows the organ to relax, leading to a natural reduction in heart muscle.
Additionally, losing weight in obese people results in increased insulin sensitivity and decreased muscle fat, which improves muscle quality.
Scientists have noted that muscle loss may be harmful for older adults. For them, drugs may be developed in the future to maintain or increase muscle mass while taking GLP-1 agonists.
Among new recommendations for stroke prevention in the United States contributed Ozempic.