Researchers from the Center for Genomic Regulation (CRG) in Barcelona have discovered special structures in eggs that protect them from damage by misfolded proteins. results published In the journal Cell.
It is stated that women’s reproductive ability depends on the presence of healthy eggs. Their numbers are limited and determined by the area called ovarian reserve. Scientists explained that eggs, unlike other cell types, cannot eliminate toxic substances through cell division. This makes them particularly susceptible to the effects of misfolded or damaged proteins.
As a result of examining thousands of immature eggs and embryos in the bodies of adult mice, scientists found that the safety of eggs until fertilization is ensured by special structures called endolysosomal vesicular mechanisms (ELVA). They move through the cytoplasm (semi-liquid content) of the eggs, where they capture, retain and neutralize protein aggregates.
Protein aggregates are misfolded pathogenic protein structures that can accumulate in the body. Misfolded protein aggregates are frequently associated with various diseases.
ELVA structures can clear the cytoplasm of eggs by destroying toxic proteins. According to scientists, this unique strategy guarantees both the quality of the egg and the quality of the future embryo.
Biologists before to create A possible cause of genetic infertility in men.