Activation of sirtuin 6 protein improves DNA damage repair in cartilage cells. A study that may help develop drugs to repair cartilage in the elderly has been published in the journal Aging.
The proper functioning of cells depends on the integrity of DNA, which can be damaged by ultraviolet radiation, toxins, and other effects. There are mechanisms to repair damaged DNA, but their effectiveness decreases with age. Previous research has shown that older people’s cartilage cells (chondrocytes) have more DNA damage than younger people’s cells.
In the new study, scientists found that activation of the SIRT6 protein using the MDL-800 molecule increased the efficiency of DNA repair in mouse chondrocytes. It also reduced the amount of initial genomic damage. In contrast, blocking SIRT6 with another molecule reduced the DNA repair rate.
Scientists believe that SIRT6 activation may be used to prevent osteoarthritis, an age-related damage to cartilage tissue, so further research is needed.
Previous scientists I learnedHe said popular ointments can cause bones to thin and cause fractures.