Scientists from the biomedical research unit at Cornell University (USA) found that those who carry a special variant of the GIP gene have a reduced susceptibility to weight gain. results published In the journal Molecular Metabolism.
An experiment involving laboratory mice showed that the Q354 variant of the GIP gene was associated with a lower risk of obesity and overweight. The research team used CRISPR-Cas9 technology to create genetically modified mice with a similar human variant of the gene encoding the GIP receptor. It turns out that when carrying the Q354 variant, the body more effectively triggers the production of insulin, which controls blood sugar levels and helps the body convert food into energy.
The GIP receptor interacts with a hormone released in response to the increase in glucose levels after a meal. Different GIP variants behave differently in cells. People with Q354 have altered metabolism so that their pancreas produces more insulin in response to sugar and increased levels of certain hormones.
The GIP receptor variant (Q354) persists in the cellular compartment four times longer than the others. This allows it to send more messages to intracellular mechanisms about the need to process and eliminate excess sugar. This feature allows transporters not to convert all glucose into fat when eating sweet and high-calorie foods.
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