Scientists at the Brigham Center for Infertility and Reproductive Surgery have used cell therapy to reverse chemotherapy-induced fertility loss in female mice. The research was published in the journal eBioMedicine.
About 5% of women suffer from premature ovarian failure due to cancer treatment or genetic problems. As the rate of cancer continues to rise among young people, the rate of chemotherapy-induced infertility is expected to increase. There is currently no treatment available to restore fertility after ovarian failure.
In an experiment on mice, scientists found that adult stem cells derived from ovarian tissue were able to restore healthy hormone levels after chemotherapy, leading to natural conception and live birth in mice.
Women with ovarian failure may lose bone mass and experience problems with sexual and heart disease. Synthetic hormone replacement therapy may help, but data on long-term use in adolescents and young adults are limited.
So far, there is no evidence that the scientists’ approach will work in humans. Also, scientists don’t know if the mice born in the experiment were completely healthy. They are now conducting long-term studies on the offspring of mice whose fertility has been restored with stem cells.
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