At the Institute of Aging Studies at the Russian National Research Medical University. NI Pirogov is conducting the RussAge study, the largest in Russia, to study the aging process; Within this framework, the authors plan to study the features of the hormonal and metabolic state of long-livers, that is, people aged 90 and over. First time in Russia. This is essential to understanding the trajectory of successful aging. This was reported to socialbites.ca at the university.
“Hormones in centenarians need to be investigated because we do not have a clear understanding in the clinic of how and in what way they should or should not affect the hormonal-metabolic state of centenarians. A large number of studies on carbohydrate metabolism in older people have now accumulated, but most respondents to such studies are under the age of 85, and the average age of the participants in our study was 93 years. cohort, ”an endocrinologist, Russian National Research Medical University, Institute for the Study of Aging, Head of the Laboratory of Aging Biomarkers, Candidate of Medical Sciences told socialbites.ca. NI Pirogova Lyubov Machekhina.
Clinical guidelines for various specialties do not allow the evaluation of the limits of reference ranges for a number of laboratory parameters, as well as the appropriateness of some drugs for use in the elderly.
In addition, the role of hormonal factors in longevity is very unclear, a more detailed assessment of them will reveal certain patterns and draw a conclusion as to what indicators should be monitored to ensure successful aging.
The study will examine multiple hormones, including carbohydrate metabolism, thyroid, and sex hormones. The hormones of adipose tissue will also be examined – this is important because inflammation of adipose tissue is part of the overall aging process. Endothelial dysfunction and slow-burning inflammation of adipose tissue are now one of the most important mechanisms of aging, including accelerated aging. Therefore, scientists need to understand how this can be regulated.
“We also look at somatotropic, tropic and peripheral hormones, insulin-like growth factor 1, cortisol and prolactin. We can say that we are looking at almost the entire hormonal spectrum,” Machekhina said.
The RussAge study also aims to create an original Russian biological age calculator. Now researchers have such tools in their arsenal, but they can give a rather large error.
Earlier gynecologist Grigorieva judicial Average age of menopause in Russian women.