Hypoxic education, which has an effect of oxygen starvation on the body, leads to a change in the work of about 500 human genes in this regard. report “socialbites.ca” was told by a geriatrician, neurologist, head of the gerontology department of MOIP at Moscow State University. MV Lomonosov Valery Novoselov.
“Complex mechanisms start to work in response to hypoxia, the hypoxia-induced factor is activated. As a result, severe epigenetic (under the influence of the environment) changes occur, about 500 genes change their job,” he said.
This conclusion was made by researchers a long time ago, for which in 2019 William Kaelin, Peter Ratcliffe and Gregg Semenza received the Nobel Prize in Physiology or Medicine.
“These changes are not hereditary, but still, at the end of life, two identical twins will look different, one of which is under the influence of hypoxia,” Novoselov said.
According to a geriatrician, during hypoxia training, an increase in the volumetric velocity of the regional blood flow occurs, its circulation changes, and the most important enzymes that ensure the inactivation of reactive oxygen species are activated: superoxide dismutase, catalase, glutathione peroxidase. In addition, glucose utilization is stimulated, glycolysis activity (glucose breakdown) increases, the number of mitochondria increases, the NO – nitrous oxide level normalizes, and the antiaggregation activity of the vascular wall improves.