Overweight and obesity are associated with an increased risk of developing gastrointestinal cancer. Ohio State University reports.
Colorectal cancer is one of the most common types of cancer in both men and women. More than 150,000 new cases of colon and rectal cancer are diagnosed each year in the United States alone.
Holly Lumans-Kropp and colleagues analyzed Archival data of 131,161 patients enrolled in a randomized clinical trial screening for prostate, lung, colorectal, and ovarian cancer. The study was conducted among participants aged 55 to 74 at enrollment between 1993 and 2001. The body mass index for these individuals was calculated based on data from their questionnaires.
The authors of the new study then categorized the participants according to WHO standards: underweight (BMI less than 18.5), normal (18.5-24.9), overweight (25-29.9), and obese (BMI above 30). on). It has been revealed that the risk of gastrointestinal system cancer is significantly increased in overweight and obese people in early, middle and advanced ages. It also found that the increase in BMI over time was associated with an increased risk of colorectal and non-colorectal gastrointestinal cancer.
This pattern is likely due to the fact that fat cells can trigger an inflammatory response and contribute to immune cell dysfunction.
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