The PEPITEM peptide reduces the risk of type 2 diabetes and other obesity-related diseases. Reported by the University of Birmingham.
Obesity causes complex and dramatic changes in adipose tissue metabolism, damage to the pancreas, decreased insulin sensitivity and ultimately the hyperglycemia underlying type 2 diabetes. It also causes a low-level inflammatory response in the body, causing white blood cells to invade many tissues, including visceral fat (found in the abdomen).
A recent study showed that PEPITEM adiponectin can suppress these effects of obesity. This was revealed during experiments on animals. When mice were fed a high-fat diet supplemented with PEPITEM, the increase in insulin-producing beta cells in the pancreas as well as visceral adipose tissue and the number of leukocytes in the abdominal cavity were significantly reduced in their bodies compared to mice. control group.
The researchers also investigated the potential for PEPITEM to reverse obesity-induced changes by feeding the animals a high-fat diet prior to PEPITEM treatment. The results were similar.
“So far we have understood little about how the inflammation that accompanies obesity leads to pathology. These results show us that PEPITEM can both prevent and reverse the effects of obesity on metabolism. The next step is to translate these results into therapeutics that can be used in humans,” commented Asif Iqbal, one of the study’s authors.
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