American scientists from Yale University have clarified the vaccination approach against respiratory diseases. They developed a new vaccination strategy that combines a traditional injection with the nasal application of the drug. The study was published scientifically magazine Nature immunology (Natimmun).
The new method, called Prime UL-SPİKE, first includes the intra-muscle application of MRNC-Ear, and then the use of a spike-shaped protein of the virus and nasal spray. It is important to indicate that the nasal component does not contain adjuvans – additional substances that may cause side effects.
The test results showed that this approach caused a strong immune response on the path of respiratory – the location of the primary penetration of the virus.
After nasal administration of experimental mice, active immunoglobulin A (IGA) production was observed in the lungs and nasal passes, which provided the first line of infection.
A feature of the approach is the participation of T cells that help V-cells to produce protective antibodies. The repeated nasal application of the drug also increased the immune response.
Researchers said that the nasal approach could not only prevent a serious course of the disease, but also prevent the infection and infection of the virus.
Previously, scientists Developed Bird, pork and vaccination from human flu for 10 years.
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Source: Gazeta
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