Scientists from the University of California in Davis found that Parasit Entamoeba Histolytica’s immune system could avoid attacks and “put on the shell of human body cells. Research Results published Journal of Parasitology (TR).
Entamoeba Histolytica (dysentery amoeba) leads 70 thousand lives a year. Typically, light causes intestinal disorders such as parasites and diarrhea, but in some cases lead to severe and sometimes fatal complications – the destruction of the intestinal walls will damage the liver, brain and lungs. At the same time, human immunity cannot always eliminate the threat.
As the Associate Professor Katherine Ralston explained by the Department of Microbiology, E. Histolytica not only destroys the cells, but also “bites içinden from them. These parts contain proteins that the parasite later placed on the surface. In particular, CD46 and CD55 proteins prevent the attack from the immune system and protect Amoebu from the effect of the complementary, the main component of congenital immunity.
Thus, the parasit moves according to the principle of biological camouflage: killing cells steals their protection to survive in the body. Previously, E. Histolytica was believed to have destroyed cells with toxins, but the observations under the microscope showed that the victim literally “eaten ..
Scientists say that the work with this organism is particularly complex because of the large genome and five times larger than the Salmonella genome and 2500 times higher in HIV. However, modern methods, including RNA parasite and CRISPR, allow you to examine the functions of individual parasite genes and monitor the behavior of proteins in real time.
The authors of the study hopes that the discoveries will pave the way for the diagnosis and treatment of amobiasis in countries with limited access to pure water and sanitation in which parasitic spread is the most active.
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Source: Gazeta
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