Scientists from the University of California have proved that the PHGDH gene directly affects the development of Alzheimer’s disease and that it was only biobelirtic as thought before. Research Results published In the magazine cell.
Alzheimer’s disease is the most common form of dementia that affects every ninth person over 65 years of age. Genetic mutations that cause the disease have been well examined, but the main causes remain uncertain. So -Called sporadic cases, which are not associated with hereditary mutations, are particularly difficult.
Researchers focused on the PHGDH gene, which was previously considered as a potential marker of early detection of the disease. However, a new study has shown that the increasing PHGDH expression level is directly related to the progression of Alzheimer’s disease. This addiction has previously been confirmed in a series of independent studies.
In order to examine such a causal relationship, scientists conducted experiments on laboratory mice and the organoids of the human brain. They found that an increase in PHGDH expression accelerates the development of the disease, on the contrary, slowed down progression. It was also found that PHGDH violated the functioning of genes in brain cells and initiated pathological processes.
In the second stage of the study, the team focused on finding connections that could prevent the PHGDH operation. The most promising candidate was the NCT-503 drug. This molecule may penetrate the hematonessic barrier and selectively affect the regulatory function of the gene.
In experiments on two groups of mouse with Alzheimer’s disease, the drug slowed down the course of the disease and normalized cognitive indicators, including memory and anxiety.
According to scientists, discoveries may be a breakthrough in the treatment of a sporadic form of Alzheimer’s disease. New data is particularly important for the successful use of artificial intelligence in the selection of therapeutic compounds.
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Source: Gazeta
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