Researchers from the University of Cornell discovered special DNA areas in the cancer cells of the brain, “genetic nodes” to complex three -dimensional structures -So. These nodes coordinate the work of many genes, including those who help tumors to develop and resist treatment. Research Results published Molecular cell in the journal.
Glioblastoma is one of the most aggressive and difficulty brain tumors. Despite significant progress in the examination of mutations, an effective way to stop the disease has not yet been found.
Dr. Weill Cornell Medical Medical Center. Effi Avari, “We tried to look at the problem differently – not through the prism of mutations, not through the spatial organization of the genome,” he said.
The human DNA, which extends to a line, reaches a length of six meters, but thanks to the dense packaging, it fits into the cage nucleus. In this packaging process in cancer cells, scientists have found that “nodes ğı are formed with the interaction of genes that are distant from each other. In the case of glioblastoma, such nodes combine both well -known oncogens and genes that were not previously related to the disease, and include them in the development of the tumor.
Using CRISPR initiative technology, scientists “turn off one of these nodes in Glioblastoma cells. This caused the domino effect – the activity of cancer genes decreased and the cells lost their ability to form tumor -like structures.
An additional analysis has shown that such a three -dimensional node is characteristic of 16 cancer types. According to scientists, these results lead to the development of new complex therapy methods, not only mutations, but also the spatial architecture of the genome in cancer cells.
Previously found Protein that increases the aggressiveness of brain cancer.
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Source: Gazeta
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