A rare gene that increases the risk of developing Alzheimer’s disease is called 16:48

Scientists from the University of Eastern Finland have found that the Finnish population significantly increased the risk of Alzheimer’s disease in the Tyrobp gene. The results of the study were published in Molecular Neurodegeneration (Molneuro).

We are talking about the partial title deed (loss) of the Tyrobp gene. Such a mutation is known as the cause of a rare hereditary disease-Nas-Hakol’s disease. This pathology manifests as bone cysts, personality changes and early dementia.

Previously, Nasu-Khakol was believed to have emerged only in people inherited by both parents by Tyrobp Delrism. However, a new study showed the following: Moving a copy of a mutated gene increases the risk of Alzheimer’s disease. In addition, in such people, the disease begins on average two years ago.

Scientists say that Tyrobp is not associated with Alzheimer’s disease earlier, because options are extremely rare in the global population, and they are almost not outside Finland. However, this gene plays an important role in the regulation of inflammation in the brain, as the Trem2 – Trem2 signal -associated Dap12 protein, which is the switch of the brain, the brain’s immune cells.

For the research, scientists chose the elderly asymptomatic carriers of Tyrobp Deealeureure of Eastern Finland. Blood samples were used to create cellular models. Comparison of these cells with the control group samples and patients with nas-hakol disease: TyrobP deletion leads to increased inflammatory reaction and the ability of cells to cope with stress.

Researchers emphasize that although the diseases of Alzheimer and Nasu-Hakola have a different clinical painting, they have general biological mechanisms. These data can be an important step in developing new methods of diagnosis and treatment of neurodegenerative diseases.

Previously, scientists open The secret of survival of dementia and neurons.