Chinese scientists from the University of Science and Technology made a breakthrough in the fight against Ospa monkeys, revealed a vulnerable part of the virus and developed new powerful inhibitors. The study was published scientifically magazine Nature.
The team focused on the switch enzyme of the virus – the main protease (Corepro), which works as “molecular scissors .. This enzyme breaks down the proteins of the virus to collect new infectious particles. Corepro Blocking converts the virus into a useless component set.
Using X-ray crystallography and cryio-electronic microscopy, the researchers first received a detailed 3D protease structure. It turned out that two mutual supportive protein molecule, similar to a dance pair.
Initially, scientists tested aloxtatine, a drug for the treatment of muscle diseases. It shows a moderate activity by “closing” the active center of the enzyme.
However, on the basis of the structures, researchers developed six new compounds that were 10-20 times more effective than Corepro. They work like “molecular adhesive, and they completely prevent the work of“ scissors .. Potentially, these substances may be active against other Pleswiruses, including natural Obs.
“This is not just a victory of monkeys of monkeys, but we create an instrument against the entire dangerous virus family,” he said.
Previously, scientists induced On the risk of transforming monkey monkeys into a threat to global health services.
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Source: Gazeta
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