Researchers from Hiroshima University and other medical institutions of Japan performed a detailed analysis of chronic liver tissues with chronic infectious liver diseases to find out which molecular changes contribute to cancer. Published in İş Magazine Proteome Research Journal (JPR).
Liver cancer may develop spontaneously, but it is associated with liver diseases (HNZP) without increasingly chronic infection. This applies to hepatoselular carcinoma, which is especially one of the most common liver cancer types. According to estimates, 15-25% of liver cancer cases develop exactly against the background of HNZP.
The researchers team examined both the expression of genes and the composition of metabolites in fabrics. This made it possible to define two subtypes of Hnzp. The first was characterized by significant inflammation and metabolic disorders associated with the second age. In both cases, changes were observed in the change of fatty acids, which are a factor that can contribute to the development of the tumor.
It was especially interesting, the essence of the Gallatin of the epallocatenin found in green tea. Previously, it has been shown to suppress inflammatory signal paths in animals with fatty liver disease. Scientists suggest that the compound can soften molecular disorders before the development of liver cancer.
“In the future, we hope that there will be preventive treatment methods aimed at eliminating certain disorders, whether or not they have inflammation or metabolic problems.” – A notch of the authors of the work, Asusi teacher.
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Source: Gazeta
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