American scientists from the University of California in Los Angeles have demonstrated how changes in the brain before and after puberty can increase the risk of autism and schizophrenia in rare genetic syndrome people. The study has been published here magazine Science Developments (SCIADV).
Experts focused on 22q11.2-A genetic disease syndrome. This significantly increases the risk of neuropsychiatric disorder, including autism and schizophrenia.
Researchers who use functional MRI in humans and genetically modified mice found that the brain shows the extreme activity of the neural networks, especially in areas responsible for social behaviors before puberty. However, after puberty, the connection decreases sharply, which is associated with the emergence of autism and symptoms of schizophrenia.
In young mice with 22q11.2 syndrome, abnormally high dendritic sudden intensity density (structures that provide connection between neurons) were observed.
After puberty, the quantities decreased sharply, which led to a violation of neural connections. Experiments inhibiting GSK3-Beta protein (regulatory synapses) temporarily restored the normal activity of the brain in mice.
Discovery offers new potential goals for the therapy that aims to prevent or reduce symptoms in people with 22q11.2 syndrome and possibly other developmental disorders.
Previously, researchers To create Genetic connection between deformation of the skull and schizophrenia.
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Source: Gazeta
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